Full list of publications:
Selected publications:
Casanova J-L, MacMicking JD and Nathan CF, Interferon-γ and infectious diseases: Lessons and prospects. Science (2024). https://www.science.org/doi/epdf/10.1126/science.adl2016
Singh A et al., Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase. Science Advances (2024). DOI:10.1126/sciadv.adj6406, https://www.science.org/doi/epdf/10.1126/sciadv.adj6406
Lee, A.M., Laurent, P., Nathan, C.F. and Barrat, F.J. Eur. J. Immunol., 2024, Neutrophil-plasmacytoid dendritic cell interaction leads to production of type I IFN in response to Mycobacterium tuberculosis. https://doi.org/10.1002/eji.202350666 https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202350666
Nathan, C, Mycobacterium tuberculosis as teacher, Nature Microbiology (2023) https://www.nature.com/articles/s41564-023-01454-3
Zhan et al., Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance, Cell Chemical Biology (2023), https://doi.org/10.1016/j.chembiol.2023.04.006
K Zainabadi, K Saito, S Mishra , K F Walsh, L D Mathurin, SC Vilbrun, O Ocheretina, J W Pape , D W Fitzgerald, C F Nathan, M H Lee. Transcriptional Biomarkers of Differentially Detectable Mycobacterium tuberculosis in Patient Sputum. mBio e02701-22, PMID: 36326252, 2022 Link
Gold B et al, Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions, ACS Infect. Dis. 2022, 8, 3, 557–573, https://doi.org/10.1021/acsinfecdis.1c00570, https://pubs.acs.org/doi/epdf/10.1021/acsinfecdis.1c00570
Zhang H, Ginn J, Zhan W, Liu YJ, Leung A, Toita A, Okamoto R, Wong TT, Imaeda T, Hara R, Yukawa T, Michino M, Vendome J, Beuming T, Sato K, Aso K, Meinke PT, Nathan CF, Kirkman LA, Lin G. Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors. J Med Chem. 14;65(13):9350-9375. 2022 PMID: 35727231. Link
Zhang L, Jiang X, Pfau D, Ling Y, Nathan CF. Type I interferon signaling mediates Mycobacterium tuberculosis-induced macrophage death. J Exp Med. 1,218 2021 Link
K. Saito, S. Mishra, T. Warrier, N. Cicchetti, J. Mi, E. Weber, X. Jiang, J. Roberts, A. Gouzy, E. Kaplan, C. D. Brown, B. Gold, C. Nathan. Oxidative damage and delayed replication allow viable Mycobacterium tuberculosis to go undetected. Science Translational Medicine 13, 2021 Link
Nathan, C. Rethinking Immunology. Science 373: 276-277, 2021 Link
S. M. Schrader, J. Vaubourgeix, C. Nathan. Biology of antimicrobial resistance and approaches to combat it. Science Translational Medicine 12, eaaz6992, 2020 Link
E. Ballinger, J. Mosior, T. Hartman, K. Burns-Huang, B. Gold, R. Morris, L. Goullieux, I. Blanc, J. Vaubourgeix, S. Lagrange, L. Fraisse, S. Sans, C. Couturier, E. Bacqué, K. Rhee, S. M. Scarry, J. Aubé, G. Yang, O. Ouerfelli, D. Schnappinger, T. R. Ioerger, C. A. Engelhart, J. A. McConnel, K. McAulay, A. Fay, C. Roubert, J. Sacchettini, C. Nathan. Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition. Science 363: eaau8959, 2019 Link
H. Yu, T. J. Lupoli, A. Kovach, X. Meng, G. Zhao, C. F. Nathan and H. Li. ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB. Proc. Natl. Acad. Sci. USA 115: E9560-E9569, 2018 Link
L. A. Kirkman, W. Zhan, J. Visone, A. Dziedziech, P. K. Singh, H. Fan, X. Tong, I. Bruzual, R. Hara, M. Kawasaki, T. Imaeda, R. Okamoto, K. Sato, M. Michino, E. Alvero, L. F. Guiang, L. Sanz, D. J. Mota, K. Fovindasamy, R. Wang, Y. Ling, P. K. Tumwebaze, G. Sukenick, L. Shi, J. Vendome, P. Bhanot, P. J. Rosenthal, K. Aso, M. A. Foley, R. A. Cooper, B. Kafsack, J. S. Doggett, C. F. Nathan and G. Lin. Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance. Proc. Natl. Acad. Sci. USA 115: E6863-E6870, 2018 Link
C. Nathan. Kunkel Lecture: Fundamental immunodeficienty and its correction. J. Exp. Med. 214: 2175-2191, 2017 PDF
K. Saito, T. Warrier, S. Somersan-Karakaya, L. Kaminski, J. Mi, X. Jiang, S. Park, K. Shigyo, B. Gold, J. Roberts, E. Weber, W. R. Jacobs, Jr., and C. Nathan. Rifamycin action on RNA polymerase in antibiotic tolerant Mycobacterium tuberculosis results in differentially detectable populations. Proc. Natl. Acad. Sci. USA 114: E4832-E4840, 2017 PDF
E. Sula Karecci, H. Fan, M. Uehara, A. Mihali, P. K. Singh, A. Kurdi, Z. Solhjou, L. Riella, I. Ghobriel, T. Laragione, S. Routray, J. P. Assaker, R. Wang, L. Shi, F. J. Barrat, C. F. Nathan, G. Lin and J. Azzi. Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proc. Natl. Acad. Sci. USA 113: E8425-E8431, 2017 PDF
T. Lupoli, A. Fay, C. Adura, M. S. Glickman and C. Nathan. Reconstitution of a proteostasis pathway in Mycobacterium tuberculosis highlights essential cofactor interactions with chaperone DnaK. Proc. Natl Acad. Sci. USA E7947-E7956, 2016 PDF
J. Vaubourgeix, G. Lin, N. Dhar, N. Chenouard, X. Jiang, H. Botella, T. Lupoli, O. Mariani, G. Yang, O. Ouerfelli, M. Unser, D. Schnappinger, J. McKinney and C. Nathan. Asymmetric distribution of irreversibly oxidized, ClpB-associated proteins in stressed mycobacteria. Cell Host and Microbe 117: 179-190, 2015 PDF
M. Nandakumar, C. Nathan and K. Y. Rhee. Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis. Nature Communications 5: 4306, 2014 PDF
R. Bryk, N. Arango, C. Maksymiuk, A. Balakrishnan, Y.-T. Wu, C.-H. Wong, T. Masquelin, P. Hipskind, C. D. Lima and C. Nathan. Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry 52: 9375-9384, 2013 PDF
Rath, P., C. Huang, T. Wang, T. Wang, H. Li, R. Prados-Rosales, O. Elemento, A. Casadevall and C. Nathan. Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 8: E4790-4797, 2013 PDF
Cunningham-Bussel, A., T. Zhang and C. F. Nathan. Nitrite produced by M. tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression. Proc. Natl. Acad. Sci. USA 110: E4256-E4265, 2013 PDF
Lin, G, T. Chidawanyika, C. Tsu, T. Warrier, J. Vaubourgeix, C. Blackburn. K. Gigstad, M. Sintchak, L. Dick and C. Nathan. N,C-capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: Role of S3 and S1 binding pockets. J. Am. Chem. Soc. 135: 9968−9971, 2013 PDF
Balakrishnan, A., F. Jordan and C. Nathan. Influence of allosteric regulators on individual steps in the reaction catalyzed by Mycobacterium tuberculosis 2-hydroxy-3-oxoadipate synthase. J. Biol. Chem. 288: 21714-21728, 2013 PDF
B. Gold, M. Pingle, S. J. Brickner, N. Shah, J. Roberts, M. Rundell, W. Clay Bracken, T. Warrier, S. Somersan, A. Venugopal, C. Darby, X. Jiang, J. D. Warren, J. Fernandez, O. Ouerfelli, E. L. Nuermberger, A. Cunningham-Bussel, P. Rath, H. Deng, R. Realubit, J. F. Glickman and C. Nathan. A non-steroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc. Natl. Acad. Sci. USA 109: 16004-16011, 2012 PDF
Venugopal, A., Bryk, R., Shi, S., Rhee, K., Rath, P., Schnappinger, D., Ehrt, S. and Nathan, C. Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multi-enzyme complexes. Cell Host and Microbe 9: 21-31, 2011 PDF